- Journal
- JOURNAL OF ORGANIC CHEMISTRY
- Année
- 2013
- Volume
- 78
- Numéro
- 11
- Pages
- 5794-5799
- Mois
- JUN 7
- DOI
- 10.1021/jo400713u
Abstract
A variety of 4-substituted 3-azabicyclo[3.1.0]hexan-2-ones have been prepared from 2-iodocyclopropane-carboxamides by a three-step sequence involving a copper-free Sonogashira coupling with terminal aryl- or heteroarylalkynes, followed by a 5-exo-dig cyclization and an ionic hydrogenation.