- Journal
- JOURNAL OF ORGANIC CHEMISTRY
- Année
- 2024
- Volume
- 89
- Numéro
- 19
- Pages
- 14073-14080
- Mois
- SEP 16
- DOI
- 10.1021/acs.joc.4c01497
Abstract
The asymmetric transfer hydrogenation of gem-difluorocyclopropenyl ketones, catalyzed by a Noyori-Ikariya ruthenium complex, was developed to access substituted optically enriched cis-disubstituted gem-difluorocyclopropyl ketones, and the value of these latter building blocks was illustrated by the synthesis of heterocycles fused to the difluorocyclopropyl moiety.