- Journal
- ORGANIC LETTERS
- Année
- 2022
- Volume
- 24
- Numéro
- 27
- Pages
- 4954-4959
- Mois
- JUL 15
- DOI
- 10.1021/acs.orglett.2c01888
Abstract
ABSTRACT: cis-1,2-Dialkenylcyclopropanes incorporating a vinyl azide, generated by Knoevenagel condensations between the corresponding cyclopropanecarbaldehydes and alpha-azido ketones, undergo cascade Cope and Winstein [3,3]-sigmatropic rearrangements, under mild conditions. The sequence allows access to diversely substituted 1,4-cycloheptadienes armed with a secondary allylic azide with up to three stereocenters.