- Journal
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Année
- 2014
- Volume
- 53
- Numéro
- 33
- Pages
- 8705-8708
- Mois
- AUG 11
- DOI
- 10.1002/anie.201401070
Abstract
With the goal of synthesizing new [n]paracyclophanes, the expansion of the scope of a strategy originally disclosed by Winterfeldt et al., was investigated. This approach involves sequential Diels-Alder/retro-Diels-Alder reactions, the applications of which have been constrained so far to steroid derivatives. An efficient access to new functionalized [9]-, [10]-, and [16]paracyclophanes, including original cage architectures, was developed from readily available building blocks using thermal electrocyclization and a cycloaddition/cycloreversion sequence as the key steps.