- Journal
- TETRAHEDRON
- Année
- 2009
- Volume
- 65
- Numéro
- 9
- Pages
- 1809-1832
- Mois
- FEB 28
- DOI
- 10.1016/j.tet.2008.10.108
Abstract
The gold-catalyzed cycloisomerizations of 1,6-ene-ynamides proceed under mild conditions and lead to cyclobutanones from terminal or trimethylsilyl Substituted ynamides, or to carbonyl compounds bearing a 2,3-methanopyrrolidine Subunit from Substrates possessing a propargylic alcohol moiety. High diastereoselectivities are observed with 1,6-ene-ynamides having a stereocenter at the or alpha or beta position of the nitrogen atom. (C) 2008 Elsevier Ltd. All rights reserved.