2012 · CARBON

How long a functionalized carbon nanotube can passively penetrate a lipid membrane

Kraszewski, Sebastian, Picaud, Fabien, Elhechmi, Imen, Gharbi, Tijani, Ramseyer, Christophe

Journal
CARBON
Année
2012
Volume
50
Numéro
14
Pages
5301-5308
Mois
NOV
DOI
10.1016/j.carbon.2012.07.018

Abstract

We explore with Molecular Dynamics simulations and a statistical model, the ability of carbon nanotubes to be internalized into a model lipid bilayer as a function of their length. The hydrophobicity is one of the key factors responsible for the insertion process. The membrane asymmetry is also needed to drive a complete translocation. Our data demonstrates that shorter nanotubes have a stronger propensity to passively penetrate the bilayer and reach the cytoplasm. Carbon nanotubes excretion appears mostly impossible whatever their length. (C) 2012 Elsevier Ltd. All rights reserved.

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