- Journal
- ORGANIC LETTERS
- Année
- 2009
- Volume
- 11
- Numéro
- 19
- Pages
- 4262-4265
- Mois
- OCT 1
- DOI
- 10.1021/ol9014877
Abstract
Iron trichloride promotes the cationic cyclization of o-(arylethynyl)aryl isocyanates leading to 3-(arylchloromethylene)oxindoles which can be stereoselectively converted to (2)-3-(aminomethylene)ox in doles under straightforward conditions. When the alkyne is substituted by an alkyl group, activation of the allylic C-H bond also occurs producing 1,2-(dichloroalkylidene)oxindoles.