2016 · JOURNAL OF MEMBRANE BIOLOGY

Nanovectorization of DNA Through Cells Using Protamine Complexation

Boukari, Khaoula, Caoduro, Cecile, Kacem, Raoudha, Skandrani, Nadia, Borg, Christophe, Boulahdour, Hatem, Gharbi, Tijani, Delage-Mourroux, Regis, Hervouet, Eric, Pudlo, Marc, Picaud, Fabien

Journal
JOURNAL OF MEMBRANE BIOLOGY
Année
2016
Volume
249
Numéro
4
Pages
493-501
Mois
AUG
DOI
10.1007/s00232-016-9890-5

Abstract

Carbon nanotubes (CNT) are currently used as a promising family of nanovectors able to deliver different types of therapeutic molecules. Several applications dealing with CNT used as drug nanocarriers have been developed since their ability to penetrate into the cells has been proved. CNT can thus load several active molecules to various cells. In this paper, we will use molecular dynamic simulation to describe theoretically the potential of CNT to transport and deliver DNA through the formation of protamine-DNA-CNT complex.

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