- Journal
- DIABETES RESEARCH AND CLINICAL PRACTICE
- Année
- 2025
- Volume
- 226
- Article
- 112302
- Mois
- AUG
- DOI
- 10.1016/j.diabres.2025.112302
Abstract
Aims: Fear of hypoglycemia limits sports in type 1 diabetes (T1D). This study aimed to evaluate the efficacy of Diabrasport glycemic management algorithms over a week with three real-life exercise sessions. Methods: A multicenter non-inferiority study including 43 adults with T1D using insulin pumps, continuous glucose monitoring was conducted over three one-week periods: rest, exercise with personal insulin algorithms (PersonalAlgo), and exercise with Diabrasport insulin algorithms (DiabraAlgo). The exercise period consisted of three sessions of 45-60 min per week of physical activity. DiabraAlgo included: (i) 100% basal rate reduction for intense post-absorptive exercise, (ii) 80% basal rate reduction during moderate exercise in the post-absorptive period and for two hours afterwards, and (iii) 50% prandial bolus reduction for moderate postprandial exercise. Results: Hypoglycemia (<70 mg/dL) was not more frequent with DiabraAlgo (0.88 +/- 0.62) during exercise than during rest (1.03 +/- 0.61) (95 % CI - 0.04 to 0.33, non-inferiority margin 0.35, p < 0.001). No difference was found between PersonalAlgo and DiabraAlgo in post-absorptive exercise, but during moderate postprandial exercise, DiabraAlgo resulted in less time in hypoglycemia (6.1 +/- 9.8 % vs. 10.5 +/- 12.8 %, p < 0.05) and fewer hypoglycemic episodes (1.0 +/- 1.1 vs. 1.4 +/- 1.3, p < 0.05). Conclusion: DiabraAlgo enables an effective adaptation of insulin levels during exercise, promoting their immediate applicability for individuals with T1D.