- Journal
- SYNTHESIS-STUTTGART
- Année
- 2025
- Volume
- 57
- Numéro
- 20
- Pages
- 2909-2934
- Mois
- OCT
- DOI
- 10.1055/a-2646-6085
Abstract
Given the growing demand for enantiomerically enriched compounds, the design of efficient, atom-economical, and sustainable synthetic strategies for the preparation of chiral alcohols and amines remains a critical objective in modern chemistry. This short, updated review highlights recent advances in homogeneous asymmetric catalysis employing transition-metal complexes in asymmetric hydrogenation (AH) and transfer hydrogenation (ATH) of ketones and imines under dynamic kinetic resolution (DKR) conditions to access these important building blocks. These methods enable the simultaneous formation of multiple stereogenic centers and have been significantly expanded through the development of novel catalytic systems and their application to previously unexplored classes of substrates.