- Journal
- ORGANIC LETTERS
- Année
- 2017
- Volume
- 19
- Numéro
- 10
- Pages
- 2706-2709
- Mois
- MAY 19
- DOI
- 10.1021/acs.orglett.7b01051
Abstract
Structurally diverse macrocyclic pyridones can be efficiently synthesized by a rhodium(III)-catalyzed C-H activation/heterocyclization of omega-allcynyl alpha-substituted acrylic hydroxamates. The use of a Omicron-pivaloyl hydroxamate as directing group was crucial to achieve efficient catalyst turnover in a redox-neutral process.