- Journal
- CHEMISTRY-A EUROPEAN JOURNAL
- Année
- 2014
- Volume
- 20
- Numéro
- 52
- Pages
- 17385-17394
- Mois
- DEC 22
- DOI
- 10.1002/chem.201404822
Abstract
The relative configuration of a key subunit of hemicalide, a recently isolated, highly bioactive marine natural product having potent antiproliferative activity against a panel of human cancer cell lines, was assigned by combining stereocontrolled synthesis of model substrates with NMR, IR, and vibrational circular dichroism (VCD) spectroscopy. The assignment of the absolute configuration of asymmetric carbon center C42 in two structurally complex epimeric substructures containing six stereocenters by VCD analysis illustrates the power and reliability of combining methods.