- Journal
- ORGANIC LETTERS
- Année
- 2015
- Volume
- 17
- Numéro
- 15
- Pages
- 3786-3789
- Mois
- AUG 7
- DOI
- 10.1021/acs.orglett.5b01759
Abstract
Glycolates or glycinates derived from diversely substituted secondary cyclopropenylcarbinols have been involved for the first time in an Ireland-Claisen rearrangement. This reaction allows an efficient and stereoselective access to highly functionalized alkylidenecyclopropanes possessing an alpha-hydroxy or a-amino acid subunit, which in turn are valuable precursors of substituted cyclopropanes by diastereoselective hydrogenation of the exocyclic alkene.