2013 · ORGANIC LETTERS

Synthetic Studies on Hemicalide: Development of a Convergent Approach toward the C1-C25 Fragment

Sorin, Geoffroy, Fleury, Etienne, Tran, Christine, Prost, Elise, Molinier, Nicolas, Sautel, Francois, Massiot, Georges, Specklin, Simon, Meyer, Christophe, Cossy, Janine, Lannou, Marie-Isabelle, Ardisson, Janick

Journal: ORGANIC LETTERS
Année: 2013
Volume: 15
Numéro: 18
Pages: 4734-4737
Mois: SEP 20
DOI: 10.1021/ol402077e

Abstract

Synthetic studies on hemicalide, a recently isolated marine natural product displaying highly potent antiproliferative activity and a unique mode of action, have highlighted a reliable Horner-Wadsworth-Emmons olefination to create the C6-C7 alkene and a remarkable efficient Suzuki-Miyaura coupling to form the C15-C16 bond, resulting in the development of a convergent approach toward the C1-C25 fragment.

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