- Journal
- TETRAHEDRON
- Année
- 2008
- Volume
- 64
- Numéro
- 28
- Pages
- 6684-6697
- Mois
- JUL 7
- DOI
- 10.1016/j.tet.2008.05.012
Abstract
Synthetic approaches toward the natural product cytostatin, an inhibitor of protein phosphatase 2A possessing cytotoxic and antimetastatic activities, have been investigated. A formal synthesis of cytostatin has been achieved according to a strategy relying on the formation of the C8-C9 bond by a nucleophilic addition of a functionalized organolithium (C1-C8 subunit) to an aldehyde (C9-C13 subunit). (C) 2008 Elsevier Ltd. All rights reserved.