- Journal
- PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Année
- 2022
- Volume
- 41
- Numéro
- 7
- Pages
- 544-548
- Mois
- JUL
- DOI
- 10.1097/INF.0000000000003529
Abstract
Aim: To determine the impact of a systematic endotracheal aspiration (ETA) sampling program for mechanically ventilated patients on initial antibiotic therapy for ventilator-acquired pneumonia (VAP). Design: Retrospective cohort study; before-after study design. Setting: Pediatric intensive care unit (PICU) with 16 medical and surgical beds in a tertiary teaching hospital. Subjects: Patients Intervention: Biweekly systematic ETA sampling was conducted in mechanically ventilated patients. Measurements: We retrospectively studied patients who received antibiotic therapy for suspected VAP 12 months before and after the initiation of systematic ETA (periods 1 and 2, respectively), evaluating the initial antibiotic therapy spectrum in both periods. Results: During period 1, 56 patients developed VAP and 47 developed VAP during period 2. The incidence was 17 cases of VAP/1000 days of mechanical ventilation in both periods. Ideal antibiotic therapy was prescribed in 19.6% of cases for period 1 and 55.2% for period 2 (P = 0.001). Initial antibiotic therapy for VAP during period 2 had a significantly lower proportion of broad-spectrum antibiotics than therapy during period 1 (P = 0.01). Conclusion: In our PICU, knowledge of bronchial colonization reduced initial broad-spectrum antibiotic use for VAP.