- Journal
- ORGANIC LETTERS
- Année
- 2008
- Volume
- 10
- Numéro
- 20
- Pages
- 4489-4492
- Mois
- OCT 16
- DOI
- 10.1021/ol801708x
Abstract
The marine natural product amphidinolide J has been synthesized according to a convergent strategy. The key steps of this synthesis include a B-alkyl Suzuki-Miyaura coupling and the addition of an alkynyllithium reagent to a Weinreb amide to build the C4-C5 and C12-C13 bonds, respectively, and a Yamaguchi macrolactonization.