- Journal
- QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
- Année
- 2021
- Volume
- 11
- Numéro
- 1
- Pages
- 172-182
- Mois
- JAN
- DOI
- 10.21037/qims-19-981
Abstract
Background: F-18-fluorocholine positron emission tomography/computed tomography (F-choline PET/ CT) is considered a cornerstone in the staging and restaging of patients with prostate cancer (PCa). The aim of this study was to retrospectively assess unusual uptakes in patients who underwent a F-choline PET/CT for the initial staging or for the restaging of a relapsing PCa. Methods: Three hundred and sixty-eight PCa patients were staged or restaged using F-choline PET/CT. Unusual uptakes were defined as uptakes occurring outside the usual paths of diffusion of PCa or as uptake in bone with a clear morphological evidence of nonmetastatic lesion. Results: We found unusual uptakes in 47/368 patients (12.8%). Among them, 41/47 presented with benign F-choline uptake, usually within lymph nodes, due to inflammatory processes (22/47). Other benign processes were found in: thyroid (3/47), adrenal gland (3/47), brain (2/47), liver (1/47), bowel (3/47), frontal sinus (1/47), lungs (4/47), parotid gland (1/47) and bone (1/47). The six remaining patients presented with a second cancer, including lymphoma (1/47), non-small cell lung cancer (4/47) and neuroendocrine tumor (1/47). Conclusions: unusual uptakes on F-choline PET/CT are quite frequent and should be explored since they may correspond to non-PCa.