Présentation
Guillaume Herlem est l’un des membres fondateurs du laboratoire Nanomédecine, créé en 2012 et devenu SINERGIES en 2018. Ses travaux expérimentaux et de modélisation portent sur l’élucidation de nouvelles réactions chimiques et électrochimiques et sur l’étude de leurs mécanismes, notamment par dynamique moléculaire ab initio.
Parcours
Titulaire d’un DEA « De la molécule aux matériaux » de l’Université Pierre-et-Marie-Curie et d’un doctorat en chimie-physique de l’Université de Franche-Comté, Guillaume Herlem a également suivi la formation HERCULES consacrée à l’utilisation des très grands instruments scientifiques. Il est habilité à diriger des recherches par l’Université de Franche-Comté.
Recherche
Ses activités associent chimie et électrochimie pour la santé, fonctionnalisation de prothèses en ePTFE, greffage de revêtements antibactériens, capteurs et biocapteurs, imagerie hyperspectrale et thermique, modélisation moléculaire et docking. Elles mobilisent notamment l’XPS, la RMN, les spectroscopies FTIR et Raman, l’électrochimie en milieu non aqueux, la microscopie à force atomique et la microscopie électrochimique à balayage (SECM).
Projet en cours
ANR PRCE AMSTOR (2025–2029) : « Aminated BN nanosheets for H₂ storage ».
Domaines d’expertise
- Biocapteurs
- Polymères fluorés
- Alkylazanides
- Dynamique moléculaire ab initio (AIMD)
- Nanovecteurs TRAIL ciblant les cellules cancéreuses
- Fonctionnalisation de prothèses en ePTFE et revêtements antibactériens
- Physico-chimie et spectroscopies (XPS, RMN, FTIR, Raman)
- Équipe
- Equipe 3 « Ingénierie pour la santé »
- Fonction
- Professeur des universités en chimie des matériaux
Liens professionnels
Affiliations de recherche
Publications
Publications rapprochées automatiquement à partir du nom d’auteur.
Traceability of Surgical Instruments: A Systematic Review
Fayad, Moustafa, Yahiaoui, Reda, Auber, Frederic, Pidoux, Herve, Hild, Olivier, Picaud, Fabien, Herlem, Guillaume, Chaussy, Yann
Molecularly imprinted polyaniline/carbon nanotube-modified pencil graphite electrode for selective detection of bisphenol A in various aquatic matrices
Bourkeb, Khaled Wassim, Abdessemed, Djamal, Alaoui-Sosse, Badr, Chronopoulou, Laura, Baaloudj, Oussama, Herlem, Guillaume
Bioorthogonal click chemistry-mediated conjugation of an anti-DR4 antibody to gold nanorods enhances its pro-apoptotic activity under near infra-red-light stimulation
Radoua, Abdelmnim, Romain, Melanie, Chazeau, Elisa, Marthouret, Nadege, Picaud, Fabien, Herlem, Guillaume, Goze, Christine, Millot, Nadine, Micheau, Olivier
Impact of Single-Walled Carbon Nanotube Functionalization on Ion and Water Molecule Transport at the Nanoscale
Mejri, Alia, Arroyo, Nicolas, Herlem, Guillaume, Palmeri, John, Manghi, Manoel, Henn, Francois, Picaud, Fabien
Direct Defluorination and Amination of Polytetrafluoroethylene and Other Fluoropolymers by Lithium Alkylamides
Herlem, Guillaume, Roina, Yaelle, Fregnaux, Mathieu, Goncalves, Anne-Marie, Cattey, Helene, Picaud, Fabien, Auber, Frederic
Nanovectorization of Ivermectin to avoid overdose of drugs
Duverger, Eric, Herlem, Guillaume, Picaud, Fabien
Fall Detection Approaches for Monitoring Elderly HealthCare Using Kinect Technology: A Survey
Fayad, Moustafa, Hachani, Mohamed-Yacine, Ghoumid, Kamal, Mostefaoui, Ahmed, Chouali, Samir, Picaud, Fabien, Herlem, Guillaume, Lajoie, Isabelle, Yahiaoui, Reda
A Perfect Challenge to Select the Ideal Virus Vaccine Using a New Potent Hierarchical Algorithm in a Smart Laboratory
Ar-Reyouchi, El Miloud, Varshney, Gunjan, Ghoumid, Kamal, Picaud, Fabien, Herlem, Guillaume, Mostefaoui, Ahmed, Yahiaoui, Reda
Sodium Naphthalenide Diglyme Solution for Etching PTFE, Characterizations and Molecular Modelization
Roina, Yaelle, Goncalves, Anne-Marie, Fregnaux, Mathieu, Auber, Frederic, Herlem, Guillaume
Molecular dynamics investigations of ionic conductance at the nanoscale: Role of the water model and geometric parameters
Mejri, Alia, Mazouzi, Kamel, Herlem, Guillaume, Picaud, Fabien, Hennequin, Theo, Palmeri, John, Manghi, Manoel
Gold modification by reduction of a diazonium salt prepared from an aliphatic diamine: a new useful means to remove hazardous substances
Kandory, Ahmed, Goncalves, Anne-Marie, Fregnaux, Mathieu, Cattey, Helene, Alaoui-Sosse, Badr, Aleya, Lotfi, Herlem, Guillaume
ePTFE-based biomedical devices: An overview of surgical efficiency
Roina, Yaelle, Auber, Frederic, Hocquet, Didier, Herlem, Guillaume
Ionic Conductance of Carbon Nanotubes: Confronting Literature Data with Nanofluidic Theory
Manghi, Manoel, Palmeri, John, Henn, Francois, Noury, Adrien, Picaud, Fabien, Herlem, Guillaume, Jourdain, Vincent
Growth, pigment changes, and photosystem II activity in the aquatic macrophyte Lemna minor exposed to bisphenol A
Bourgeade, Pascale, Aleya, Enis, Alaoui-Sosse, Laurence, Herlem, Guillaume, Alaoui-Sosse, Badr, Bourioug, Mohamed
From Behavior of Water on Hydrophobic Graphene Surfaces to Ultra-Confinement of Water in Carbon Nanotubes
Mejri, Alia, Herlem, Guillaume, Picaud, Fabien
Confinement of the antitumoral drug cisplatin inside edge-functionalized carbon nanotubes and its release near lipid membrane
Mejri, Alia, Tangour, Bahoueddine, Herlem, Guillaume, Picaud, Fabien
Breaking the Controversy of the Electropolymerization of Pyrrole Mechanisms by the Effective Screening Medium Quantum Charged Model Interface
Herlem, Guillaume, Picaud, Fabien
A potential solution to avoid overdose of mixed drugs in the event of Covid-19: Nanomedicine at the heart of the Covid-19 pandemic
Duverger, Eric, Herlem, Guillaume, Picaud, Fabien
The influence of hole networks on the adsorption-induced frequency shift of a perforated nanobeam using non-local elasticity theory
Bourouina, Hicham, Yahiaoui, Reda, Kerid, Rachid, Ghoumid, Kamal, Lajoie, Isabelle, Picaud, Fabien, Herlem, Guillaume
Ligand nanovectorization using graphene to target cellular death receptors of cancer cell
Arroyo, Nicolas, Herlem, Guillaume, Picaud, Fabien
From Anodic Oxidation of Aliphatic α-Amino Acids to Polypeptides by Quantum Electrochemistry Approach: Beyond Miller-Urey Experiments
Herlem, Guillaume, Alhedabi, Taleb, Picaud, Fabien
Carbon Nanotubes: Synthesis, Characterization, and Applications in Drug-Delivery Systems
Herlem, Guillaume, Picaud, Fabien, Girardet, Claude, Micheau, Olivier
Controlled modification of electrochemical microsystems with polyethylenimine/reduced graphene oxide using electrophoretic deposition: Sensing of dopamine levels in meat samples
Kahlouche, Karima, Jijie, Roxana, Hosu, Ioana, Barras, Alexandre, Gharbi, Tijani, Yahiaoui, Reda, Herlem, Guillaume, Ferhat, Marhoun, Szunerits, Sabine, Boukherroub, Rabah
Shear effect on dynamic behavior of microcantilever beam with manufacturing process defects
Bourouina, Hicham, Yahiaoui, Reda, Yusifli, Elmar, Benamar, Mohammed El Amine, Ghoumid, Kamal, Herlem, Guillaume
N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death
Dufour, Florent, Rattier, Thibault, Shirley, Sarah, Picarda, Gaelle, Constantinescu, Andrei Alexandru, Morle, Aymeric, Zakaria, Al Batoul, Marcion, Guillaume, Causse, Sebastien, Szegezdi, Eva, Zajonc, Dirk Michael, Seigneuric, Renaud, Guichard, Gilles, Gharbi, Tijani, Picaud, Fabien, Herlem, Guillaume, Garrido, Carmen, Schneider, Pascal, Benedict, Chris Alan, Micheau, Olivier
FPGA-Based HD Camera System for the Micropositioning of Biomedical Micro-Objects Using a Contactless Micro-Conveyor
Yusifli, Elmar, Yahiaoui, Reda, Qaisar, Saeed Mian, Addouche, Mahmoud, Al-Mahdawi, Basil, Bourouina, Hicham, Herlem, Guillaume, Gharbi, Tijani
Experimental and theoretical studies on electropolymerization of polar amino acids on platinum electrode
Alhedabi, Taleb, Cattey, Helene, Roussel, Christophe, Blondeau-Patissier, Virginie, Gharbi, Tijani, Herlem, Guillaume
Electrochemical Deposition of a Luminescent Alkoxysilyl-Based Fluorenone Film Exhibiting Halide Sensitivity
Herlem, Guillaume, Kandory, Ahmed, Tangou, Rodolphe Kinghat, Gharbi, Tijani, Cattey, Helene, Knorr, Michael, Khatyr, Abderrahim
Direct Writing on Copper Ion Doped Silica Films by Electrogeneration of Metallic Microstructures
Kandory, Ahmed, Cattey, Helene, Saviot, Lucien, Gharbi, Tijani, Vigneron, Jackie, Fregnaux, Mathieu, Etcheberry, Arnaud, Herlem, Guillaume
Synthesis, regioselectivity, and DFT analysis of new antioxidant pyrazolo[4,3-c]quinoline-3,4-diones
Tomassoli, Isabelle, Herlem, Guillaume, Picaud, Fabien, Benchekroun, Mohamed, Bautista-Aguilera, Oscar M., Luzet, Vincent, Jimeno, Maria-Luisa, Gharbi, Tijani, Refouvelet, Bernard, Ismaili, Lhassane
Enhanced DR5 binding capacity of nanovectorized TRAIL compared to its cytotoxic version by affinity chromatography and molecular docking studies
Zakaria, Albatoul, Picaud, Fabien, Guillaume, Yves Claude, Gharbi, Tijani, Micheau, Olivier, Herlem, Guillaume
Electrogeneration of Diiodoaurate in Dimethylsulfoxide on Gold Substrate and Localized Patterning
Kandory, Ahmed, Yahiaoui, Reda, Herth, Etienne, Cattey, Helene, Gharbi, Tijani, Herlem, Guillaume
Nanovectorization of TRAIL with Single Wall Carbon Nanotubes Enhances Tumor Cell Killing
Zakaria, Al Batoul, Picaud, Fabien, Rattier, Thibault, Pudlo, Marc, Saviot, Lucien, Chassagnon, Remi, Lherminier, Jeannine, Gharbi, Tijani, Micheau, Olivier, Herlem, Guillaume
Nanovectorization of TRAIL with Single Wall Carbon Nanotubes Enhances Tumor Cell Killing (vol 15, pg 891, 2005)
Zakaria, Al Batoul, Picaud, Fabien, Rattier, Thibault, Pudlo, Marc, Dufour, Florent, Saviot, Lucien, Chassagnon, Remi, Lherminier, Jeannine, Gharbi, Tijani, Micheau, Olivier, Herlem, Guillaume
Nanovector formation by functionalization of TRAIL ligand on single-walled carbon nanotube: Experimental and theoretical evidences
Zakaria, Al Batoul, Picaud, Fabien, Duverger, Eric, Devaux, Xavier, Delabrousse, Eric, Gharbi, Tijani, Micheaud, Olivier, Herlem, Guillaume
Electrochemistry of pertechnetate on ultramicroelectrode: A new quality control for radiopharmaceuticals manufactured at hospital in nuclear medicine
Herlem, Guillaume, Angoue, Orland, Gharbi, Tijani, Boulahdour, Hatem
Electrosynthesis of Poly(alanine)-Like Peptides in Concentrated Alanine Based Electrolytes, Characterization Coupled to DFT Study and Application to pH Proton Receptor
Alhedabi, Taleb, Herlem, Guillaume, Cattey, Helene, Blondeau-Patissier, Virginie, Gharbi, Tijani
A Reverse Engineering Method for DMU Maturity Management: Use of a Functional Reeb Graph
Herlem, Guillaume, Ducellier, Guillaume, Adragna, Pierre-Antoine, Durupt, Alexandre, Remy, Sebastien
DMU Maturity Management as an Extension of the Core Product Model
Herlem, Guillaume, Adragna, Pierre-Antoine, Ducellier, Guillaume, Durupt, Alexandre
Soft Adsorption of Densely Packed Layers of DNA-Plasmid 1,3-Diaminopropane Complexes onto Highly Oriented Pyrolitic Graphite Designed To Erode in Water
Boulanouar, Omar, Khatyr, Abderrahim, Herlem, Guillaume, Palmino, Frank, Sanche, Leon, Fromm, Michel
Simple method for detection of extremely diluted anti beta-casein antibodies from glass bead based receptors
Antoniou, Alexandros, Herlem, Guillaume, Andre, Claire, Guillaume, Yves, Gharbi, Tijani
Electrodeposition of Insulating Thin Film Polymers from Aliphatic Monomers as Transducers for Biosensor Applications
Herlem, Guillaume, Gharbi, Tijani
A new arginase enzymatic reactor: Development and application for the research of plant-derived inhibitors
Andre, Claire, Herlem, Guillaume, Gharbi, Tijani, Guillaume, Yves Claude
One-pot electrosynthesis of polyglycine-like thin film on platinum electrodes as transducer for solid state pH measurements
Herlem, Guillaume, Zeggari, Rabah, Rauch, Jean-Yves, Monney, Sandrine, Anzola, Freddy Torrealba, Guillaume, Yves, Andre, Claire, Gharbi, Tijani
Experimental studies of OH° radical/pressure dependence of arginase activity using a molecular chromatography approach
Andre, Claire, Ibrahim, Firas, Gharbi, Tijani, Herlem, Guillaume, Guillaume, Yves Claude
Electrochemically deposited polyethyleneimine films and their characterization
Segut, Olivier, Herlem, Guillaume, Lakard, Boris, Blondeau-Patissier, Virginie, Nardin, Michel, Gree, Simon, Rauch, Jean-Yves
Analyzing ab initio infrared spectra and electronic properties of polyethylenimine water complexes in the solid state
Herlem, Guillaume, Gharbi, Tijani, Ben Sedrine, Nebiha
Electrocatalyzed synthesis of polypeptides on platinum surface in concentrated glycine electrolytes and ab initio calculations coupled to spectroscopic analysis
Herlem, Guillaume, Monney, Sandrine, Blondeau-Patissier, Virginie, Fahys, Bernard, Gharbi, Tijani
Electrodeposition and characterization of silane thin films from 3-(aminopropyl)triethoxysilane
Herlem, Guillaume, Segut, Olivier, Antoniou, Alexandros, Achilleos, Christine, Dupont, Didier, Blondeau-Patissier, Virginie, Gharbi, Tijani
Electrochemical polymerization of 1,2-ethanedithiol as a new way to synthesize polyethylenedi sulfide
Lakard, Boris, Herlem, Guillaume, Fahys, Bernard
Synthesis of polymer materials for use as cell culture substrates
Lakard, Sophie, Morrand-Villeneuve, Nadge, Lesniewska, Eric, Lakard, Boris, Michel, Germaine, Herlem, Guillaume, Gharbi, Tijani, Fahys, Bernard
Potentiometric miniaturized pH sensors based on polypyrrole films
Lakard, Boris, Segut, Olivier, Lakard, Sophie, Herlem, Guillaume, Gharbi, Tijani
Development of miniaturized pH biosensors based on electrosynthesized polymer films
Segut, Olivier, Lakard, Boris, Herlem, Guillaume, Rauch, Jean-Yves, Jeannot, Jean-Claude, Robert, Laurent, Fahys, Bernard