Présentation
Fabien Picaud développe une activité scientifique à l’interface de la physique moléculaire, de la physique des surfaces, des nanosciences, de la chimie quantique et de la biophysique. Ses recherches, centrées sur les applications biomédicales, mobilisent des outils numériques et théoriques pour étudier notamment les nanofils, les nanoréseaux, les nanopores et les canaux biologiques. Elles contribuent au développement d’approches en nanomédecine, biomimétisme et théranostique.
Parcours
Fabien Picaud a suivi un cursus complet en physique à l’Université de Franche-Comté, du DEUG au DEA, avant de préparer une thèse consacrée à la nanostructuration des surfaces, soutenue en 2001. Après un séjour postdoctoral à la SISSA de Trieste, il est devenu maître de conférences en 2004 et a obtenu son habilitation à diriger des recherches en 2007. Il est directeur adjoint du laboratoire SINERGIES.
Recherche et enseignement
Ses travaux ont évolué de la physique des surfaces et des nano-objets vers la simulation moléculaire, la nanomédecine, la filtration biomimétique et les stratégies de vectorisation anticancéreuse. Il est également responsable d’enseignements dans le cadre du diplôme d’accès aux études universitaires (DAEU).
Projets de recherche
Ses activités comprennent notamment les projets ANR IONESCO, NanoOligo, AMSTOR, Caneloni et nanoTRAIL_Lighter, ainsi que des projets de calcul intensif GENCI et CRIANN.
Domaines d’expertise
- Nanofils et nanoréseaux
- Nanopores
- Canaux biologiques
- Nanomédecine
- Biomimétisme
- Théranostique
- Simulation moléculaire
- Équipe
- Equipe 3 « Ingénierie pour la santé »
- Fonction
- MCF-HDR – Directeur adjoint du laboratoire SINERGIES
Liens professionnels
Affiliations de recherche
Publications
Publications rapprochées automatiquement à partir du nom d’auteur.
Traceability of Surgical Instruments: A Systematic Review
Fayad, Moustafa, Yahiaoui, Reda, Auber, Frederic, Pidoux, Herve, Hild, Olivier, Picaud, Fabien, Herlem, Guillaume, Chaussy, Yann
Effect of pyrimethanil on aβ42 aggregation mechanisms revealed at single entity level and molecular dynamic simulations
Meyer, Nathan, Arroyo, Nicolas, Roustan, Lois, Janot, Jean-Marc, Perrier, Veronique, Torrent, Joan, Picaud, Fabien, Balme, Sebastien
Concanavalin A adsorption on gold nanoparticles: Influence of citrate ions on nanoparticle-protein interactions
Lahouari, Sephora, Gouyon, Jeremie, Francius, Gregory, Picaud, Fabien, dos Reis, Roberta Albino, Seabra, Amedea B., Clarot, Igor, Boudier, Ariane
Bioorthogonal click chemistry-mediated conjugation of an anti-DR4 antibody to gold nanorods enhances its pro-apoptotic activity under near infra-red-light stimulation
Radoua, Abdelmnim, Romain, Melanie, Chazeau, Elisa, Marthouret, Nadege, Picaud, Fabien, Herlem, Guillaume, Goze, Christine, Millot, Nadine, Micheau, Olivier
Secondary Nucleation of Aβ Revealed by Single-Molecule and Computational Approaches
Meyer, Nathan, Arroyo, Nicolas, Roustan, Lois, Janot, Jean-Marc, Charles-Achille, Saly, Torrent, Joan, Picaud, Fabien, Balme, Sebastien
Impact of Single-Walled Carbon Nanotube Functionalization on Ion and Water Molecule Transport at the Nanoscale
Mejri, Alia, Arroyo, Nicolas, Herlem, Guillaume, Palmeri, John, Manghi, Manoel, Henn, Francois, Picaud, Fabien
Direct Defluorination and Amination of Polytetrafluoroethylene and Other Fluoropolymers by Lithium Alkylamides
Herlem, Guillaume, Roina, Yaelle, Fregnaux, Mathieu, Goncalves, Anne-Marie, Cattey, Helene, Picaud, Fabien, Auber, Frederic
Ultrasensitive Detection of Aβ42 Seeds in Cerebrospinal Fluid with a Nanopipette-Based Real-Time Fast Amyloid Seeding and Translocation Assay
Meyer, Nathan, Bentin, Jeremy, Janot, Jean-Marc, Abrao-Nemeir, Imad, Charles-Achille, Saly, Pratlong, Maud, Aquilina, Alexis, Trinquet, Eric, Perrier, Veronique, Picaud, Fabien, Torrent, Joan, Balme, Sebastien
Translocation Processes of Pt(II)-Based Drugs through Human Breast Cancer Cell Membrane: In Silico Experiments
Almeida, Eduardo R., Goliatt, Priscila V. Z. Capriles, Dos Santos, Helio F., Picaud, Fabien
New insights into phosphorus biphilicity: Stereochemistry of monocyclic aminophosphoranes formation
Mejri, Alia, Fliss, Outaf, Essalah, Khaled, Boughdiri, Mohamed Ali, Picaud, Fabien, Tangour, Bahoueddine, Sayari, Abdelhamid
Nanovectorization of Ivermectin to avoid overdose of drugs
Duverger, Eric, Herlem, Guillaume, Picaud, Fabien
Modeling the Cellular Uptake of Functionalized Carbon Nanohorns Loaded with Cisplatin through a Breast Cancer Cell Membrane
Almeida, Eduardo R., Goliatt, Priscila V. Z. Capriles, Dos Santos, Heïlio F., Picaud, Fabien
Fall Detection Approaches for Monitoring Elderly HealthCare Using Kinect Technology: A Survey
Fayad, Moustafa, Hachani, Mohamed-Yacine, Ghoumid, Kamal, Mostefaoui, Ahmed, Chouali, Samir, Picaud, Fabien, Herlem, Guillaume, Lajoie, Isabelle, Yahiaoui, Reda
A Perfect Challenge to Select the Ideal Virus Vaccine Using a New Potent Hierarchical Algorithm in a Smart Laboratory
Ar-Reyouchi, El Miloud, Varshney, Gunjan, Ghoumid, Kamal, Picaud, Fabien, Herlem, Guillaume, Mostefaoui, Ahmed, Yahiaoui, Reda
Molecular dynamics investigations of ionic conductance at the nanoscale: Role of the water model and geometric parameters
Mejri, Alia, Mazouzi, Kamel, Herlem, Guillaume, Picaud, Fabien, Hennequin, Theo, Palmeri, John, Manghi, Manoel
Investigation of α-Synuclein and Amyloid-β(42)-E22Δ Oligomers Using SiN Nanopore Functionalized with L-Dopa
Abrao-Nemeir, Imad, Bentin, Jeremy, Meyer, Nathan, Janot, Jean-Marc, Torrent, Joan, Picaud, Fabien, Balme, Sebastien
Conical nanopores highlight the pro-aggregating effects of pyrimethanil fungicide on Aβ(1-42) peptides and dimeric splitting phenomena
Meyer, Nathan, Arroyo, Nicolas, Baldelli, Matteo, Coquart, Nicolas, Janot, Jean Marc, Perrier, Veronique, Chinappi, Mauro, Picaud, Fabien, Torrent, Joan, Balme, Sebastien
Ionic Conductance of Carbon Nanotubes: Confronting Literature Data with Nanofluidic Theory
Manghi, Manoel, Palmeri, John, Henn, Francois, Noury, Adrien, Picaud, Fabien, Herlem, Guillaume, Jourdain, Vincent
Impact of surface state on polyethylene glycol conformation confined inside a nanopore
Arroyo, Nicolas, Balme, Sebastien, Picaud, Fabien
From Behavior of Water on Hydrophobic Graphene Surfaces to Ultra-Confinement of Water in Carbon Nanotubes
Mejri, Alia, Herlem, Guillaume, Picaud, Fabien
Detection of Amyloid-β Fibrils Using Track-Etched Nanopores: Effect of Geometry and Crowding
Meyer, Nathan, Arroyo, Nicolas, Janot, Jean-Marc, Lepoitevin, Mathilde, Stevenson, Anna, Nemeir, Imad Abrao, Perrier, Veronique, Bougard, Daisy, Belondrade, Maxime, Cot, Didier, Bentin, Jeremy, Picaud, Fabien, Torrent, Joan, Balme, Sebastien
Conformation of Polyethylene Glycol inside Confined Space: Simulation and Experimental Approaches
Ma, Tianji, Arroyo, Nicolas, Marc Janot, Jean, Picaud, Fabien, Balme, Sebastien
Confinement of the antitumoral drug cisplatin inside edge-functionalized carbon nanotubes and its release near lipid membrane
Mejri, Alia, Tangour, Bahoueddine, Herlem, Guillaume, Picaud, Fabien
Breaking the Controversy of the Electropolymerization of Pyrrole Mechanisms by the Effective Screening Medium Quantum Charged Model Interface
Herlem, Guillaume, Picaud, Fabien
A potential solution to avoid overdose of mixed drugs in the event of Covid-19: Nanomedicine at the heart of the Covid-19 pandemic
Duverger, Eric, Herlem, Guillaume, Picaud, Fabien
The influence of hole networks on the adsorption-induced frequency shift of a perforated nanobeam using non-local elasticity theory
Bourouina, Hicham, Yahiaoui, Reda, Kerid, Rachid, Ghoumid, Kamal, Lajoie, Isabelle, Picaud, Fabien, Herlem, Guillaume
Polynucleotide differentiation using hybrid solid-state nanopore functionalizing with α-hemolysin
Bentin, Jeremy, Balme, Sebastien, Picaud, Fabien
Ligand nanovectorization using graphene to target cellular death receptors of cancer cell
Arroyo, Nicolas, Herlem, Guillaume, Picaud, Fabien
First-principles study of the reaction mechanism governing the SNAr of the dimethylamine on 2-methoxy-5-nitrothiophenes
Smaoui, Amal, Essalah, Khaled, Boubaker, Taoufik, Assfeld, Xavier, Picaud, Fabien, Tangour, Bahouedine
Behavior of anchor functionalized ZnPc molecules on a graphene nanoflake near membrane cell
Picaud, Fabien, Duverger, Eric, Stauffer, Louise, Sonnet, Philippe
Influence of nanotube section on carboplatin confinement
Bentin, Jeremy, Duverger, Eric, Picaud, Fabien
From Anodic Oxidation of Aliphatic α-Amino Acids to Polypeptides by Quantum Electrochemistry Approach: Beyond Miller-Urey Experiments
Herlem, Guillaume, Alhedabi, Taleb, Picaud, Fabien
Carbon Nanotubes: Synthesis, Characterization, and Applications in Drug-Delivery Systems
Herlem, Guillaume, Picaud, Fabien, Girardet, Claude, Micheau, Olivier
Unexpected ionic transport behavior in hydrophobic and uncharged conical nanopores
Balme, Sebastien, Picaud, Fabien, Lepoitevin, Mathilde, Bechelany, Mikhael, Balanzat, Emmanuel, Janot, Jean-Marc
The encapsulation of the gemcitabine anticancer drug into grapheme nest: a theoretical study
Mlaouah, Marwa, Tangour, Bahoueddine, El Khalifi, Mohammed, Gharbi, Tijani, Picaud, Fabien
Voltage-activated transport of ions through single-walled carbon nanotubes
Yazda, Khadija, Tahir, Said, Michel, Thierry, Loubet, Bastien, Manghi, Manoel, Bentin, Jeremy, Picaud, Fabien, Palmeri, John, Henn, Francois, Jourdain, Vincent
Simulations of a Graphene Nanoflake as a Nanovector To Improve ZnPc Phototherapy Toxicity: From Vacuum to Cell Membrane
Duverger, Eric, Picaud, Fabien, Stauffer, Louise, Sonnet, Philippe
N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death
Dufour, Florent, Rattier, Thibault, Shirley, Sarah, Picarda, Gaelle, Constantinescu, Andrei Alexandru, Morle, Aymeric, Zakaria, Al Batoul, Marcion, Guillaume, Causse, Sebastien, Szegezdi, Eva, Zajonc, Dirk Michael, Seigneuric, Renaud, Guichard, Gilles, Gharbi, Tijani, Picaud, Fabien, Herlem, Guillaume, Garrido, Carmen, Schneider, Pascal, Benedict, Chris Alan, Micheau, Olivier
Discrimination of Polynucleotide Transport through a Highly Hydrophobic Uncharged Nanopore
Picaud, Fabien, Paris, Guillaume, Gharbi, Tijani, Lepoitevin, Mathilde, Coulon, Pierre-Eugene, Bechelany, Mikhael, Janot, Jean Marc, Balme, Sebastien
Controlling activation barrier by carbon nanotubes as nano-chemical reactors
Mejri, Alia, Picaud, Fabien, El Khalifi, Mohammed, Gharbi, Tijani, Tangour, Bahoueddine
Boron Nitride Nanoporous Membranes with High Surface Charge by Atomic Layer Deposition
Weber, Matthieu, Koonkaew, Boonprakrong, Balme, Sebastien, Utke, Ivo, Picaud, Fabien, Iatsunskyi, Igor, Coy, Emerson, Miele, Philippe, Bechelany, Mikhael
Towards New Insights in the Sterol/Amphotericin Nanochannels Formation: A Molecular Dynamic Simulation Study
Boukari, Khaoula, Balme, Sebastien, Janot, Jean-Marc, Picaud, Fabien
Synthesis, regioselectivity, and DFT analysis of new antioxidant pyrazolo[4,3-c]quinoline-3,4-diones
Tomassoli, Isabelle, Herlem, Guillaume, Picaud, Fabien, Benchekroun, Mohamed, Bautista-Aguilera, Oscar M., Luzet, Vincent, Jimeno, Maria-Luisa, Gharbi, Tijani, Refouvelet, Bernard, Ismaili, Lhassane
Selectivity against proton in cation permeable hybrid solid state membrane
Picaud, Fabien, Boukari, Khaoula, Balme, Sebastien, Janot, Jean Marc, Henn, Francois
Nanovectorization of DNA Through Cells Using Protamine Complexation
Boukari, Khaoula, Caoduro, Cecile, Kacem, Raoudha, Skandrani, Nadia, Borg, Christophe, Boulahdour, Hatem, Gharbi, Tijani, Delage-Mourroux, Regis, Hervouet, Eric, Pudlo, Marc, Picaud, Fabien
Ionic Transport through Uncharged Nanopores
Balme, Sebastien, Picaud, Fabien, Manghi, Manoel, Palmeri, John, Bechelany, Mikhael, Balanzat, Emmanuel, Janot, Jean-Marc
Enhanced DR5 binding capacity of nanovectorized TRAIL compared to its cytotoxic version by affinity chromatography and molecular docking studies
Zakaria, Albatoul, Picaud, Fabien, Guillaume, Yves Claude, Gharbi, Tijani, Micheau, Olivier, Herlem, Guillaume
Electronic and optical properties of CeO2 from first principles calculations
El Khalifi, Mohammed, Picaud, Fabien, Bizi, Mohamed
Confined Nystatin Polyenes in Nanopore Induce Biologic Ionic Selectivity
Boukari, Khaoula, Paris, Guillaume, Gharbi, Tijani, Balme, Sebastien, Janot, Jean-Marc, Picaud, Fabien
Carbon nanotube - Protamine hybrid: Evaluation of DNA cell penetration
Caoduro, Cecile, Kacem, Raoudha, Boukari, Khaoula, Picaud, Fabien, Brachais, Claire-Helene, Monchaud, David, Borg, Christophe, Boulandour, Hatem, Gharbi, Tijani, Delage-Mourroux, Regis, Hervouet, Eric, Pudlo, Marc
Biomimetic solution against dewetting in a highly hydrophobic nanopore
Picaud, Fabien, Paris, Guillaume, Gharbi, Tijani, Balme, Sebastien, Lepoitevin, Mathilde, Tangaraj, Vidhyadevi, Bechelany, Mikhael, Janot, Jean Marc, Balanzat, Emmanuel, Henn, Francois
Theoretical demonstration of the potentiality of boron nitride nanotubes to encapsulate anticancer molecule
El Khalifi, Mohammed, Duverger, Eric, Gharbi, Tijani, Boulandour, Hatem, Picaud, Fabien
Nanovectorization of TRAIL with Single Wall Carbon Nanotubes Enhances Tumor Cell Killing
Zakaria, Al Batoul, Picaud, Fabien, Rattier, Thibault, Pudlo, Marc, Saviot, Lucien, Chassagnon, Remi, Lherminier, Jeannine, Gharbi, Tijani, Micheau, Olivier, Herlem, Guillaume
Nanovectorization of TRAIL with Single Wall Carbon Nanotubes Enhances Tumor Cell Killing (vol 15, pg 891, 2005)
Zakaria, Al Batoul, Picaud, Fabien, Rattier, Thibault, Pudlo, Marc, Dufour, Florent, Saviot, Lucien, Chassagnon, Remi, Lherminier, Jeannine, Gharbi, Tijani, Micheau, Olivier, Herlem, Guillaume
Nanovector formation by functionalization of TRAIL ligand on single-walled carbon nanotube: Experimental and theoretical evidences
Zakaria, Al Batoul, Picaud, Fabien, Duverger, Eric, Devaux, Xavier, Delabrousse, Eric, Gharbi, Tijani, Micheaud, Olivier, Herlem, Guillaume
Ionic transport through sub-10 nm diameter hydrophobic high-aspect ratio nanopores: experiment, theory and simulation
Balme, Sebastien, Picaud, Fabien, Manghi, Manoel, Palmeri, John, Bechelany, Mikhael, Cabello-Aguilar, Simon, Abou-Chaaya, Adib, Miele, Philippe, Balanzat, Emmanuel, Janot, Jean Marc
Encapsulation into Carbon Nanotubes and Release of Anticancer Cisplatin Drug Molecule
Mejri, Alia, Vardanega, Delphine, Tangour, Bahoueddine, Gharbi, Tijani, Picaud, Fabien
Quantum study of boron nitride nanotubes functionalized with anticancer molecules
Duverger, Eric, Gharbi, Tijani, Delabrousse, Eric, Picaud, Fabien
Ionic selectivity of nystatin A1 confined in nanoporous track-etched polymer membrane
Balme, Sebastien, Thiele, Daniela, Kraszewski, Sebastian, Picaud, Fabien, Janot, Jean-Marc, Dejardin, Philippe
Structure and ionic selectivity of a hybrid polyene/artificial polymer solid state membrane
Thiele, Daniela, Kraszewski, Sebastian, Balme, Sebastien, Picaud, Fabien, Janot, Jean-Marc, Dejardin, Philippe
Enhanced potassium selectivity in a bioinspired solid nanopore
Picaud, Fabien, Kraszewski, Sebastian, Ramseyer, Christophe, Balme, Sebastien, Dejardin, Philippe, Janot, Jean Marc, Henn, Francois
Enhanced Ionic Transport Mechanism by Gramicidin A Confined Inside Nanopores Tuned by Atomic Layer Deposition
Abou Chaaya, Adib, Le Poitevin, Mathilde, Cabello-Aguilar, Simon, Balme, Sebastien, Bechelany, Mikhael, Kraszewski, Sebastian, Picaud, Fabien, cambedouzou, Julien, Balanzat, Emmanuel, Janot, Jean-Marc, Thami, Thierry, Miele, Philippe, Dejardin, Philippe
Efficiency of the monofunctionalized C60 fullerenes as membrane targeting agents studied by all-atom molecular dynamics simulations
Yesylevskyy, Semen O., Kraszewski, Sebastian, Picaud, Fabien, Ramseyer, Christophe
Controlling potassium selectivity and proton blocking in a hybrid biological/solid-state polymer nanoporous membrane
Balme, Sebastien, Picaud, Fabien, Kraszewski, Sebastian, Dejardin, Philippe, Janot, Jean Marc, Lepoitevin, Mathilde, Capomanes, Jhon, Ramseyer, Christophe, Henn, Francois
How long a functionalized carbon nanotube can passively penetrate a lipid membrane
Kraszewski, Sebastian, Picaud, Fabien, Elhechmi, Imen, Gharbi, Tijani, Ramseyer, Christophe
New Bioinspired Membrane Made of a Biological Ion Channel Confined into the Cylindrical Nanopore of a Solid-State Polymer.
Balme, Sebastien, Janot, Jean-Marc, Berardo, Lydie, Henn, Francois, Bonhenry, Daniel, Kraszewski, Sebastian, Picaud, Fabien, Ramseyer, Christophe
Formation of one-dimensional ordered alloy at step edges: An atomistic study of the (2 x 1) Ni/Pt alloy on the Pt(997) surface
Essolaani, Wafa, Picaud, Fabien, Ramseyer, Christophe, Gambardella, Pietro, Said, Moncef, Spanjaard, Daniel, Desjonqueres, Marie-Catherine
Growth of perfect and smooth Ag and Co monatomic wires on Pt vicinal surfaces: A kinetic Monte Carlo study
Garbouj, Hedi, Said, Moncef, Picaud, Fabien, Ramseyer, Christophe, Spanjaard, Daniel, Desjonqueres, Marie-Catherine
First stages of epitaxial growth in the presence of an extended defect: Kinetic Monte Carlo simulations versus rate equation study on a vicinal surface
Dumont, Florent, Ramadan, Ali, Picaud, Fabien, Ramseyer, Christophe, Girardet, Claude
A stable room-temperature molecular assembly of zwitterionic organic dipoles guided by a Si(111)-7x7 template effect
Makoudi, Younes, Arab, Madjid, Palmino, Frank, Duverger, Eric, Ramseyer, Christophe, Picaud, Fabien, Cherioux, Frederic